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doi: 10.3389/fimmu.2020.01007 Received 21 February 2020 Accepted 28 April 2020 Published 28 May 2020 Volume 11 - 2020 Edited by Laxmi Yeruva, University of Arkansas for Medical Sciences, United States Reviewed by Barbara Wrblewska, Institute of Animal Reproduction and Food Research (PAN), Poland

64 Even though CVC has a differentiated mechanism of action compared to OCA and Resmetirom, weaker efficacy data compared to both those candidates have reduced confidence in the drugs efficacy as a monotherapy (see Figure 3)

This study is centered around the effects of HMB supplementation on oxygen capacity for endurance athletes, which found that blood glucose was significantly greater during HMB use and concludes that HMB supplementation may have positive effects on performance[12]

A 2024 review surveyed neurotransmitter-system interactions in this body of work (PMID 38675421), suggesting the compound's effects on central nervous system tissue may share mechanisms with its peripheral activity